Views:1 Author:Site Editor Publish Time: 2021-10-15 Origin:Site
Myocardial infarction is one of the diseases with the highest mortality rate of cardiovascular diseases. Myocardial infarction is due to coronary artery stenosis or spasm, leading to acute or persistent myocardial ischemia and hypoxia, and myocardial cell death. Various pro-inflammatory cytokines such as interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) are involved in myocardial remodeling3. SR9011 is a REV-ERBα/β agonist and a member of the nuclear receptor family. Studies have found that it has the effect of regulating the metabolism of biological tissues. Huang Guodong's research found that SR9011 has an important regulatory effect on the rhythm of zebrafish autophagy genes.
The C-terminus of the SR9011 family protein lacks a domain that can bind to a ligand, but it can inhibit the expression of Rev-erb protein by recruiting nuclear receptor inhibitors and histone deacetylase 3, etc. Histone deacetylase 3 is a Rev-erb agonist and a small molecule chemical probe. Fon-taine et al. first reported that there is a correlation between SR9011 and inflammation. SR9011 can inhibit the expression of Tr4, thereby controlling inflammation signals. Foreign scholars have found that in human macrophages, the use of pharmacological methods to increase the mRNA expression of SR9011 directly leads to a decrease in the mRNA expression of the pro-inflammatory factor interleukin-6.