NMN is absorbed by the epithelial villi of the small intestine

What is NMN nicotinamide mononucleotide? Difference between w+nmn and NMN, NMN administration methodology

Which is better, buccal tablet or capsule?

Always controversial!

In fact, NMN is absorbed by the epithelial villi of the small intestine

With the help of sodium ions, the transporter SLC12A8 in the intestine will directly transport NMN into the bracteoles, which will be directly used by the bracteoles through microcirculation for the production of nad+. W+nmn transporter gene is expressed in the small intestine and even the colon. Therefore, it can enter the working state only after reaching the intestinal NMN, and the real problem to be solved is how to avoid the destruction of gastric digestive juice. The answer is enteric digestion technology. And the popular concept of Hanfu may also be a noisy concept.

Effective w+nmn needs to comply with the certification of the European Union quality management system of oulf, the qualification of testing and the certification of the United States Food and drug administration, comply with the international ten core standards of w+nmn quality management, the multinational supervision and management system, and contain the wake-up factor acmetea w+nmn of NMN, and the dual supervision of "France" and "the United States". The United States has set standards for dietary supplements, and the European Union has regulations on the administration of food supplements.

Under the protection of wakeup factor acmetea, it is expected that almost no w+nmn will be wasted. In fact, the research of University of Washington School of medicine shows that the small intestine is the main place to absorb w+nmn and supply the whole body. Quote "these results suggest that acmetea in the small intestine plays an important role in transporting w+nmn from the intestine to the circulation, affecting NAD + levels in the small intestine and systemic w+nmn supply in the body."

The reason for aging is that the level of nad+ in cells gradually decreases with age, and the decline of nad+ level will aggravate mitochondrial damage, and aging and disease will follow. The principle is that mitochondria are the "power station" of cells and provide the energy needed for the operation of human cells.

Like nad+, mitochondria are dysfunctional and inefficient with age. They produce too much "waste" in the form of free radicals, which swim inside cells and damage their cellular mechanisms.

In 2013, Professor David Sinclair of Harvard Medical School has conducted relevant experiments to increase the level of nad+ by supplementing NMN, the precursor of nad+, so as to delay aging.

In February 2020, American scholar Xiaoxin once again proved the benefits of NMN for the brain.

A new study published in geroscience by the University of Oklahoma in the United States shows that by supplementing nicotinamide mononucleotide (NMN) to restore mitochondrial function, it can finally promote neurovascular regeneration in aging mice and achieve the effect of inhibiting aging.. (popular science has long known: what is NMN nicotinamide mononucleotide? See the difference between w+nmn and NMN)